The Nb₄₄Ti₂₈Ni_28-xFe_x（x=0, 5, 10, 15） ingots were prepared by the non-consumable vacuum arc melting. The microstructure of the ingot was analyzed by the scanning electron microscope（SEM-Quanta 200 FEG） and X-ray diffraction analysis. The results reveal that microstructure of Nb₄₄Ti₂₈Ni_28-xFe_x alloys is composed of the primary phases and eutectics when x≤10, while the NbFe phases are precipitated in the subeutectic structure when x>10. The hydrogen solubility, hydrogen permeability and hydrogen diffusion of Nb₄₄Ti₂₈Ni_28-xFe_x（x=0, 5, 10） alloys were systematically investigated. The results indicate that the hydrogen solubility of alloys is slightly decreased with the increase of Fe content, while the permeability is increased at first and then decreased. The Nb₄₄Ti₂₈Ni₂₃Fe₅ alloy exhibits the optimal hydrogen permeability at temperatures above 523 K, and it is 1.5 times higher than that of Nb₄₄Ti₂₈Ni₂₈ alloy at 673 K, which mainly benefits from the substantially increase of intrinsic hydrogen diffusion coefficient.