High temperature compression testing for Ti-6Al-2Zr-1Mo-1V alloy was carried out by thermecmastor-Z simulator with strain rate from 0.1 to 10s-1 and 50% deformation degree at 750¹100℃. Effects of deformed processing parameters on the flow stress were examined, and stress exponent and activation energy were calculated at different temperatures, meanwhile, the hyperbolic sine constitutive equation for the alloy was established. The results indicate that true stress-strain curves of the alloy are characterized by flow softening behavior at 750⁹50℃ while it is characterized by steady flow behavior at 1000¹100℃. In addition, deformation activation energy Q is 828.9kJ/mol at 750¹000℃ and 197.1kJ/mol at 1000¹100℃, showing different deformation mechanism at different temperature ranges.