Thermal simulation compressive experiment was conducted for semi-solid 6063 aluminum alloy billets which was prepared by near-liquidus semi-continuous casting. Based on stress-strain curves at varied temperatures and strain rates,inverse-squeezing process of the semi-solid 6063 aluminum alloy was simulated by the Deform-3D software at 615⁶25 ℃ with strain rate of 0.1⁵s-1 and 60% deformation rate to understand effects of deformation rate,deformation temperature,punch velocity and frictional coefficient and to optimize the processing parameters. The results reveal that with increasing in deformation rates,flow velocity and flow orientation of the alloy in severe deformation zone are distinctly changed,meanwhile,light deformation zone is gradually evolved,which results in the remarkable non-uniformity of deformation. With raising in punch velocity,flow velocity of the billets is accelerated,which is harmful for the formation as a result of aggravating non-uniformity of the whole deformation process. With deformation temperature increase,equivalent strain of the billets in severe deformation zone is obviously increased,while equivalent stress in the billets is decreased. Effects of frictional states on the deformation of billets can be neglected.