Wear-resistance of Ti-48Al-2Cr-2Nb prepared by metallic mold centrifugal casting was tested in the conditions of casting and hot isostatic press （1 270 ℃/173 MPa/4 h）. Experimental results reveal that the friction coefficient of as-cast samples is bout 0.140 with loading of 50 N for 10 min or loading of 100 N for 5min, while the friction coefficient of HIP treated alloy sample is about 0.158 with loading of 50 N for 10 min or loading of 100 N for 3 min. The microstructural observation indicates that the influence of HIP on friction coefficient of TiAl based alloy is attributed to eliminating shrinkage porosity in the samples to improve the compactness of the alloy and to convert the structure of the alloy from full laminar into duplex-structure.