Ni-based powder that can form the cladding coating with 10 mm in thickness and smooth surface and gas hole-crack free is successfully prepared based on the analysis of powder materials requirements in laser cladding process. The results reveal that the thermal expansion coefficient of the Ni-based cladding coating is less than that of 45# steel matrix,resulting in the absence of crack in pressure during solidification. Fe and Co elements in powder are beneficial to improving the properties of the cladding coating to decrease the crack susceptibility. Non-complete bulk amorphous phase in the Ni-based cladding coating can be observed,which can greatly improve the crack resistance of the cladding coating because of its desirable mechanical properties.