High entropy alloys with a multi-principal element design

which can complement the traditional alloy design concept

are capable of achieving excellent comprehensive performance

thus presenting significant potential for practical applications in the industrial field. At present

many limitations still exist in the current research of high-entropy alloys

such as the time-consuming

high-cost R & D processes and the incomplete basic theories. Multi-scale modeling and simulation are playing a key role in material science

which can provide an efficient way for the design and micro-scale mechanistic study of high-entropy alloys. Applications of different multi-scale modeling and simulation methods in the research of high entropy alloys during the past years were reviewed

and some future research directions were also prospected.